Pharmacokinetics and dosimetry in intraperitoneal - GUPEA
Klinisk prövning på CD38 Positive: Astatine At 211 Anti-CD38
9,420, 1.7E-06 3, Bi Ll. 9,658, 0.74 7, Po Ll. 10,731, 3.3E-06 6, Bi La2. 10,839, 3.0E-05 5, Bi La1. Apr 14, 2020 Oncotarget Volume 11 Issue 15 reported that C6 glioma, U-87MG, and GL261 cell lines were subjected to a cellular 211At-PA uptake analysis Astatine-211 Meta-Astatobenzylguanidine ([211At]MABG) Targeted Radiotherapy for Disseminated Neuroblastoma · Background. Neuroblastoma is a childhood A “wet chemistry” approach for isolation of 211At from an irradiated bismuth target is described. The approach involves five steps: (1) dissolution of bismuth The aim of this study was to estimate human dosimetry from preclinical biodistribution of free 211At and 211At-MABG in various organs in normal mice. Methods: At is a promising radionuclide for α-particle therapy of cancers.
Both 211At-ET210-28 and 211At-ET210-6 could specifically kill mesothelin-positive cells with negligible damages to mesothelin-negative cells. Our findings provide initial proof-of-concept for the potential use of 211At labeled ET210-28/ET210-6 anti-mesothelin antibody in specific killings of mesothelin-positive tumor cells. There is some debate as to the best incident α-particle energy for maximizing 211At production while minimizing production of (210)At, which is problematic because of its 138.4-day half life α-particle emitting daughter, (210)Po. The intrinsic cost for producing (211)At is reasonably modest and comparable to that of commercially available (123)I. Intel® Ethernet Controller I211-AT specifications, features, Intel technology compatibility, reviews, pricing, and where to buy.
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211At-BC8-B10 Followed by Donor Stem Cell Transplant in Treating Patients With Relapsed or Refractory High-Risk Acute Leukemia or Myelodysplastic Syndrome The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. α-Particle–emitting radionuclides, such as 211 At, with a 7.2-h half-life, may be optimally suited for the molecularly targeted radiotherapy of strategically sensitive tumor sites, such as those in the central nervous system. 211 At is a promising radionuclide for α-particle therapy of cancers.
211 Medarbetare - KI Staff portal - Karolinska Institutet
• Wet extraction. Jun 28, 2017 Recently, 211At has received increasing attention as a potential radionuclide for cancer radioimmunotherapy. It is a α-particle emitter, which is Jun 1, 2002 The data showed that 211At is useful for vascular-targeted radioimmunotherapy because Biodistribution of 211At MAb 201B in BALB/c mice. Jul 21, 2017 The partitioning of 211At from an irradiated bismuth target using solvent extraction into several organic solvents is presented.
• Wet extraction. Jun 28, 2017 Recently, 211At has received increasing attention as a potential radionuclide for cancer radioimmunotherapy. It is a α-particle emitter, which is
Jun 1, 2002 The data showed that 211At is useful for vascular-targeted radioimmunotherapy because Biodistribution of 211At MAb 201B in BALB/c mice. Jul 21, 2017 The partitioning of 211At from an irradiated bismuth target using solvent extraction into several organic solvents is presented. Although astatine
Jun 1, 1989 Chromatography at Fixed Redox Potential of Inorganic Forms of Astatine (211At). ALAIN CAVALLERO and KURT ROESSLER.
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Transcriptional response in mouse thyroid tissue after 211At administration: effects of absorbed dose, dose-rate and time after administration Delarbete 4 Nils Rudqvist, Johan Spetz, Emil Schüler, Toshima Z. Parris, Britta Langen, Khalil Helou, Eva Forssell-Aronsson. Gene expression signature in mouse thyroid tissue after 131I and 211At exposure
The most commonly used α-emitting radionuclides are 213Bi, 211At, 223Ra and 225Ac. While each one of these has pros and cons, it can be argued that 211At probably is the most versatile based on its half life, decay scheme and chemistry. 211At radioimmunotherapy of subcutaneous human ovarian cancer xenografts: evaluation of relative biologic effectiveness of an alpha-emitter in vivo.
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