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To donate: Aim: Surgery for drug resistant epilepsy (DRE) with focal cortical dysplasia (FCD) often requires multiple non-invasive as well as invasive pre-surgical evaluations and innovative surgical strategies. Epilepsy surgery in children with focal cortical dysplasia (FCD): results of long-term seizure outcome. The purpose of this study was to assess the effect of epilepsy surgery on seizure outcome in children and adolescents under 18 years with intractable epilepsy due to focal cortical dysplasia. Surgery for focal cortical dysplasia S. M. Sisodiya Department of Clinical and Experimental Epilepsy, Institute of Neurology, UCL, Queen Square, London WC1N 3BG, UK, E-mail: sisodiya@ion.ucl.ac.uk Cortical dysplasia is the most common substrate in pediatric and the second or third most frequent etiology in adult epilepsy surgery patients.
To donate: Guerrini R, Duchowny M, Jayakar P, et al. (2015) Diagnostic methods and treatment options for focal cortical dysplasia. Epilepsia 56: 1669-1686. 12. Terra VC, Thomé U, Rosset SS, Funayama SS, dos Santos AC, et al. (2014) Surgery for focal cortical dysplasia in children using intraoperative mapping. Childs Nerv Syst 30: 1839-1851.
Postoperativt resultat för epilepsi i samband med typ I-fokala
Neuronal migration disorder refers to a disturbance in Surgical treatment is a option for refractory epilepsy with FCD and complete resection of FCD area is the major prognostic factor. Complete resection of early ictal onset zone and resection which includes the area with pathological delta waves and frequent interictal spikes predict good surgical outcome.
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This condition is one of the most common causes of epilepsy and seizures. In contemporary surgical series, cortical dysplasia is the most common substrate found in patients undergoing epilepsy neurosurgery younger than age 18 years, and the third most frequent lesion identified in adult epilepsy surgery patients (Becker et al., 2006; Harvey et al., 2008). 2018-05-01 · Background: Epilepsy surgery for focal cortical dysplasia type II (FCD II) offers good chances for seizure freedom, but remains a challenge with respect to lesion detection, defining the epileptogenic zone and the optimal resection strategy. Focal cortical dysplasia (FCD) surgery is one of the most appropriate indications for using SWE guidance.
Cereb Cortex 2015;25(7):1897-905.
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There are both genetic and acquired factors that are involved in the development of cortical dysplasia. Mild malformation of cortical development (mMCD) and focal cortical dysplasia (FCD) subtypes combined are by far the most common histological diagnoses in children who undergo surgery as treatment for refractory epilepsy.
However, even in cases where surgery is performed, up to 40% of these children may still have seizures. ocal cortical dysplasia (FCD) is a common cause of intractable epilepsy in children and often requires surgical intervention. Following first surgery, 33%– 54% of patients continue to have seizures.1,3,6,7,10,14,20 In such cases, a decision must be made on whether to undertake further resection, and to what extent the resection in the re-
Cortical Dysplasia For more information, please visit our Epilepsy Treatment Program site.
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Zoë Morris - Karolinska Institutet - Stockholm, Stockholm
Complete resection of early ictal onset zone and resection which includes the area with pathological delta waves and frequent interictal spikes predict good surgical outcome. When a cortical dysplasia is a cause of epilepsy, then seizure medications (anticonvulsants) are a first line treatment.